Complement System
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Current Projects and Interests:

Mechanisms of Complement-induced Injury — We have shown that complement is activated immediately upon reperfusion of the ischemic myocardium. Administration of murine anti-porcine C5a or anti-rat C5 monoclonal antibody (MoAb) attenuates reperfusion induced myocardial injury. Current studies investigate the mechanisms involved in this protection (i.e., decreased PMN activation/adherence, preservation of endothelial cell integrity, etc.).

Complement and Endothelial Dysfunction — The effects of complement on the vascular endothelium are not well characterized. We have shown that complement activation directly attenuates endothelium-dependent relaxation of vascular smooth muscle. Further, C5 plays an important role in the upregulation of adherence molecules via NF-kB translocation and cGMP mechanisms. We are investigating the effects of oxidative stress on complement activation in vitro and in vivo.

Publications and Manuscripts
1995 1996 1997 1998 1999 2000 2001 2002 2003
2004 2005 2006 2007 2008 2009 2010 2011 2012