Human endothelial cells exposed to oxidative stress. The nuclei are stained with PI (red), Green is complement C3 and Blue is MBL (mannose binding lectin).
(click thumbnail for closeup)
Publications and Manuscripts — PDF downloads of publications require the Acrobat Reader (which can be found here ).

Stahl GL, Reenstra WR, Frendl G.
Complement mediated loss of endothelium-dependent relaxation of porcine coronary arteries. Role of the terminal membrane attack complex.
Circulation Research 1995; 76:575-583 Download PDF

Friedman M, Wang SY, Stahl GL, Johnson RG, Sellke FW.
Altered β-adrenergic and cholinergic pulmonary vascular responses after cardiopulmonary bypass.
J. Appl. Physiol.1995;79:1998-2006 Download PDF

Amsterdam EA, Stahl GL, Pan H-L, Rendig SV, Fletcher MP, Longhurst JC.
Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs.
American Journal of Physiology 1995; 268:H448-H457 Download PDF

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Lennon PF, Collard CD, Morrissey MA, Stahl GL.
Complement mediated loss of endothelium-dependent relaxation of rabbit thoracic aorta: Mechanisms, recovery, and gender differences.
American Journal of Physiology 1996;270:H1924-H1932 Download PDF

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Collard CD, Vakeva AP, Bukusoglu C, Zund G, Sperati CJ, Colgan SP and Stahl GL.
Reoxygenation of hypoxic human umbilical vein endothelial cells activates the classic complement pathway.
Circulation 1997; 96:326-33 Download PDF

Stahl GL, Morse DS, Martin SL.
Eicosanoid production from porcine neutrophils and platelets: Differential production with various agonists.
American Journal of Physiology (Cell Physiology) 1997; 272:C1821-8 Download PDF

Zund G, Uezono S, Stahl GL, Dzus AL, McGowan FX, Hickey PR, Colgan SP.
Hypoxia enhances induction of endothelial ICAM-1: Role for metabolic acidosis and proteasomes.
American Journal of Physiology (Cell Physiology) 1997; 273:C1571-80 Download PDF

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Vakeva AP, Agah A, Rollins, SA, Matis LA, Li L and Stahl GL.
Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: Role of the terminal complement components and inhibition by anti-C5 therapy.
Circulation 1998; 97:2259-67 Download PDF

Tofukuji M, Stahl GL, Agah A, Metais C, Simons M and Sellke FW.
Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction.
Journal of Thoracic and Cardiovascular Surgery 1998; 116:1060-8 Download PDF

Lennon PF, Taylor CT, Stahl GL, Colgan SP.
Neutrophil-derived 5'AMP promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2b receptor activation.
Journal of Experimental Medicine 1998; 188:1433-43 Download PDF

Collard CD, Agah A, Stahl GL.
Complement activation following reoxygenation of hypoxic human endothelial cells: Role of intracellular reactive oxygen species, NF-.B and new protein synthesis.
Immunopharmacology 1998; 39:39-50 Download PDF

Blume ED, Taylor CT, Lennon PF, Stahl GL, Colgan SP.
Activated endothelial cells elicit paracrine induction of epithelial chloride secretion: 6-keto-PGF1. is an epithelial secretagogue.
Journal of Clinical Investigation 1998; 102:1161-72 Download PDF

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Fitch JCK, Rollins S, Matis L, Alford B, Aranki S, Collard CD, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, OHara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl GL, Shernan S.
Pharmacology and biological efficacy of a recombinant, humanized, single chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery utilizing cardiopulmonary bypass.
Circulation 1999; 100:2499 - 2506 Download PDF

Collard CD, Bukusoglu C, Agah A, Colgan SP, Reenstra WR, Morgan BP and Stahl GL.
Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells.
American Journal of Physiology (Cell Physiology) 1999; 276:C450-C458 Download PDF

Collard CD, Agah A, Reenstra W, Buras J and Stahl GL.
Endothelial nuclear factor-kB translocation and vascular cell adhesion molecule-1 induction by complement: Inhibition with anti-human C5 therapy or cGMP analogues.
Arteriosclerosis, Thrombosis and Vascular Biology 1999; 19:2623-2629 Download PDF

Szebeni J, Fontana JL Wassef NM, Mongan PD, Morse DS, Dobbins DE, Stahl GL, Bunger R, Alving CR.
Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: A model for pseudo-allergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody.
Circulation 1999; 99:2302-9 Download PDF

Park KW, Tofukuji M, Metais C, Comunale ME, Dai HB, Simons M, Stahl GL, Agah A, Sellke FW.
Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a.
Anesthesia and Analgesia 1999; 89:42-8 Download PDF

Collard CD, Lekowski R, Jordan JE, Agah A and Stahl GL.
Complement activation following oxidative stress (REVIEW).
Molecular Immunology 1999; 36:941-8 Download PDF

Tofukyji M, Metais C, Collard CD, Morse DS, Stahl GL, Nelson DP, Li J, Simons M, Sellke FW.
Effect of sialyl Lewis. -oligosaccharide on myocardial and cerebral injury in the pig.
Annals of Thoracic Surgery 1999; 67:112-9 Download PDF

Clish CB, O'Brien JA, Gronert K, Stahl GL, Petasis NA, Serhan CN.
Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo.
Proceedings of the National Academy of Sciences 1999; 96:8247-52 Download PDF

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Tofukuji M, Stahl GL, Matais C, Tomita M, Agah A, Bianchi C, Fink MP, and Sellke FW.
Mesenteric dysfunction after extracorporal circulation: Role of complement C5a.
Annals of Thoracic Surgery 2000; 69:799-807 Download PDF

Zhou W, Farrar CA, Abe K, Pratt JR, Marsh JE, Wang Y, Stahl GL and Sacks SH.
Predominant role of C5b-9 in renal ischemia/reperfusion injury.
Journal of Clinical Investigation 2000; 105:1363-71 Download PDF

Agah A, Montalto MC, Kiesecker CL, Morrissey M, Grover M, Whoolery KL, Rother RP and Stahl GL.
Isolation, characterization and cloning of porcine complement component C7.
Journal of Immunology 2000; 165:1059-65 Download PDF

Collard CD, Vakeva A, Morrissey MA, Agah A, Rollins SA, Reenstra WR, Buras JA, Meri S, and Stahl GL.
Complement activation following oxidative stress: Role of the lectin complement pathway.
American Journal of Pathology 2000; 156:1549-56 Download PDF

Buras JA, Stahl GL, Svoboda KS, Reenstra WR.
Hyperbaric oxygen down-regulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS.
American Journal of Physiology (Cell Physiology) 2000; 278:C292-C302 Download PDF

Qui F-H, Wada K, Stahl GL, Serhan CN.
IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment.
Proceedings of the National Academy of Sciences 2000; 97:4267-72 Download PDF

Szebeni J, Baranyi L, Savay S, Bodo M, Morse DS, Basta M, Stahl GL, Bunger R, Alving CR.
Liposome-induced pulmonary hypertension in pigs: properties and mechanism of a complement-mediated pseudoallergic reaction.
American Journal of Physiology (Heart and Circulatory Physiology) 2000; 279:H1319-28 Download PDF

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Wada K, Montalto MC, Stahl GL.
Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat.
Gastroenterology 2001; 120:126-33 Download PDF

Wada K, Qiu F-H, Stahl GL, Serhan CN.
Inosine monophosphate (IMP) and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: Additive actions of two new endogenous anti-inflammatory mediators.
Journal of Hematotherapy and Stem Cell Research 2001; 10:75-9

Stahl GL.
Reperfusion injury in surgery. Role of the endothelium, oxidative stress and complement activation (Invited review).
New Surgery 2001; 1:62-6

Agah A, Montalto MC, Young K, Stahl GL.
Isolation, cloning and functional characterization of porcine mannose-binding lectin.
Immunology 2001; 102:338-43 Download PDF

Montalto MC, Collard CD, Buras JA, Reenstra WR, McClaine R, Geis D, Rother RP, Stahl GL.
A keratin peptide inhibits mannose-binding lectin.
Journal of Immunology 2001; 166:4148-53 Download PDF

Collard CD, Montalto MC, Reenstra WR, Buras JA, Stahl GL.
Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin1 (CK1).
American Journal of Pathology 2001; 159:1045-54 Download PDF

Jordan JE, Montalto MC, Stahl GL.
Inhibition of mannose binding lectin reduces postischemic myocardial reperfusion injury.
Circulation 2001; 104:1413-8 Download PDF

Roos A, Bouwman LH, van Gijlswijk-Janssen DJ, Faber-Krol MC, Stahl GL, Daha MR.
Human IgA activates the complement system via the mannan-binding lectin pathway.
Journal of Immunology 2001; 167: 2861-8 Download PDF

Lekowski R, Collard CD, Reenstra WR, Stahl GL.
Ulex europaeus agglutinin II (UEA II) is a novel and potent inhibitor of complement activation.
Protein Science 2001; 10:277-84 Download PDF

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Zhao H, Wakamiya N, Suzuki Y, Hamonko MT, Stahl GL.
Identification of human mannose binding lectin (MBL) recognition sites for novel inhibitory antibodies.
Hybridoma and Hybridomics 2002; 21:25-36 Download PDF

Zhao H, Montalto MC, Pfeiffer KJ, Hao L, Stahl GL.
Murine model of gastrointestinal ischemia associated with complement dependent injury.
Journal of Applied Physiology 2002; 93:338-45 Download PDF

Collard CD, Park KA, Montalto MC, Alipati S, Buras JA, Stahl GL, Colgan SP.
Neutrophil-derived glutamate regulates vascular endothelial barrier function.
Journal of Biological Chemistry 2002; 277:14801-11 Download PDF

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Bhole DL, Stahl GL.
Therapeutic potential of targeting the complement cascade in critical care medicine.
Journal of Critical Care Medicine (Invited Review) 2003; 31:s97-s104 Download PDF

Zhao H, Miller M, Pfeiffer K, Buras JA, Stahl GL.
Anoxia and reoxygenation of human endothelial cells decreases ceramide glucosyltransferase expression and activates caspases.
FASEB Journal 2003; express article 10.1096/fj.02-0806fje. Published online February 5, 2003. FASEB Journal 2003;17:723-4 Download PDF

Jain A, Batista EL, Serhan CN, Stahl GL, Van Dyke TE.
Role for periodontitis in the progression oflipid depostion in an animal model.
Infection and Immunity 2003; 71:6012-8 Download PDF

Lawrence DW, Bruyninckx WJ, Louis DM, Stahl GL, Parkos CA, and Colgan SP.
Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia.
Journal of Experimental Medicine 2003: 198:999-1010 (cover issue) Download PDF

Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE.
Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators.
Journal of Immunology 2003; 171:6856-65 (cover issue) Download PDF

Stahl GL, Xu Y, Hao L, Miller M, Buras JA, Fung M, Zhao H.
Role for the alternative complement pathway in ischemia/reperfusion injury.
American Journal of Pathology 2003; 162:449-55 (Commentary provided by Riedemann RC and Ward PA. Complement in Ischemia Reperfusion Injury. Am J Pathol 2003;162:363-7) Download PDF Download Commentary PDF

Montalto MC, Hart ML, Jordan JE, Wada K, Stahl GL.
Role for complement in mediating intestinal nitric-oxide synthase2 and superoxide dismutase expression.
American Journal of Physiology: Gatrointestinal and Liver Physiology 2003; 285:G197-206 Download PDF

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Ohira T, Bannenberg G, Arita M, Takahashi M, Ge Q, Van Dyke TE, Stahl GL, Serhan CN, Badwey JA.
A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte specific protein 1 in human neutrophils.
Journal of Immunology 2004; 173:2091-8 Download PDF

Walsh MC, Hart ML, Bourcier TM, Bhole D, Takahashi M, Stahl GL.
Role of complement in myocardial ischemia and infarction.
In: Szebeni J, editor. The Complement System. Novel Roles in Health and Disease. Kluwer Academic Publishers. Boston, Massachusetts, 2004; Chapter 19, pages 421-36

Pachori AS, Melo LG, Hart ML, Noiseux N, Zhang L, Morello F, Solomon SD, Stahl GL, Pratt RE, Dzau VJ.
Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury.
Proceedings of the National Academy of Sciences 2004; 101:12282-7 Download PDF

Bhole D and Stahl GL.
Molecular basis for complement component 6 (C6) deficiency in rats and mice.
Immunobiology 2004; 209:559-68 Download PDF

Khan TA, Bianchi C, Voisine P, Feng J, Hart M, Takahashi M, Stahl G, Sellke FW.
Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest.
Journal of Thoracic and Cardiovascular Surgery 2004; 128:602-8 Download PDF

Hart ML, Walsh MC, Stahl GL.
Initiation of complement activation following oxidative stress. In vitro and in vivo observations.
Molecular Immunology 2004; 41:165-71 Download PDF

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Walsh MC, Bourcier T, Takahashi K, Shi L, Busche MN, Rother RP, Solomon SD, Ezekowitz RAB, Stahl GL.
Mannose binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury.
Journal of Immunology 2005; 175: 541-6 Download PDF

Buras J, Rice L, Orlow D, Pavlides S, Reenstra WR, Ceonzo K, Stahl GL.
Inhibition of C5 or absence of C6 protects against sepsis mortality.
Immunobiology 2005; 209:629-35 Download PDF

Rice L, Orlow D, Ceonzo K, Stahl GL, Tzianabos AO, Wada H, Aird WC,
CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on IL-17.
Journal of Infectious Disease. 2005; 191:1368-76 Download PDF

Hart ML, Ceonzo KA, Shaffer LA, Takahashi K, Rother R, Reenstra WR, Buras JA, Stahl GL.
Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q.
Journal of Immunology 2005; 174:6373-80 (cover issue) Download PDF

Peng T, Hao L, Madri J, Su X, Elias JA, Stahl G, Squinto S, Wang Y.
Role of C5 in the development of airway inflammation, airway hyperresponsiveness and ongoing airway response.
Journal of Clinical Investigation 2005; 115: 1590-1600 Download PDF

Cho JH, Fraser IP, Fukase K, Kusumoto S, Stahl GL, Ezekowitz RAB.
Binding specificity and activity of human Peptidoglycan Recognition Protein-S (PGRP-S): role in neutrophil-mediated innate immunity.
Blood 2005; 106:2551-8 Download PDF

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Ceonzo K, Gaynor A, Shaffer L, Kojima K, Vacanti CA, Stahl GL.
Polyglycolic acid-induced inflammation: Role of hydrolysis and resulting complement activation.
Tissue Engineering 2006; 12:301-8 Download PDF

Harboe M, Garred P, Borgen MS, Stahl GL, Roos A, Mollnes TE.
Design of a complement lectin pathway specific activation system applicable at low serum dilutions.
Clinical and Experimental Immunology 2006;144:512-20 Download PDF

Roos A, Rastaldi MP, Calvaresi N, Oortwifn BD, Schlagwein N, van Gijlswijk-Janssen DJ, Stahl GL, Matsushita M, Fujita T, van Kooten C, Daha MR.
Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease.
Journal of the American Society of Nephrology 2006; 17:1724-34 Download PDF

Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y.
Role of complement component C5 in cerebral ischemia/reperfusion injury.
Brain Research 2006; 1100:142-51 Download PDF

McMullen ME, Hart ML, Walsh MC, Buras J, Takahashi K and Stahl GL.
Mannose binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo.
Immunobiology 2006; 211:759-66 (Epub July 28, 2006) (cover issue) Download PDF

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Ganter MT, Brohi K, Cohen MJ, Shaffer LA, Walsh MC, Stahl GL, Pittet JF.
Role of the alternative pathway in the early complement activation following major trauma.
Shock; 2007, 28:29-34 Download PDF

Peckham RM, Handrigan MT, Bentley TB, Falabella MJ, Chrovian AD, Stahl GL, Tsokos GC.
C5-blocking antibody reduces fluid requirements and improves responsiveness to fluid infusion in hemorrhagic shock managed with hypotensive resuscitation.
Journal of Applied Physiology 2007; 102:673-80 Download PDF

You, Z, Yang J, Takahashi K, Yager P, Kim H-H, Qin T, Stahl GL, Ezekowitz A, Carroll M, Whalen M.
Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4.
Journal of Cerebral Blood Flow & Metabolism 2007; 27:1954-64

Walsh MC, Shaffer LA, Guikema BJ, Body SC, Shernan SK, Fox AA, Collard CD, Fung M, Taylor RP, Stahl GL.
Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage.
Journal of Immunological Methods 2007; 323:147-59 Download PDF

Griffin RS, Costigan M, Brenner GJ, Ma CHE, Scholz J, Moss A, Allchorne AJ, Stahl GL, Woolf CJ.
Complement induction in spinal cord microglia results in anaphylatoxin C5a mediated pain hypersensitivity.
Journal of Neuroscience 2007; 27:8699-708 (cover issue) Download PDF

Murata K, Fox-Talbot K, Qian Z, Takahashi K, Stahl GL, Baldwin WM, Wasowska BA.
Synergistic deposition of C4d by complement-activating and nonactivating antibodies in cardiac transplants.
American Journal of Transplantation 2007; 7:2605-14 Download PDF

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Yager PH, You Z, Qin T, Kim H-H, Takahashi K, Ezekowitz RAB, Stahl GL, Carroll MC, Whalen MJ.
Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice.
Journal of Cerebral Blood Flow & Metabolism 2008; 28:1030-9 Download PDF

La Bonte LR, Davis-Gorman G, Stahl GL, McDonagh PF.
Complement inhibition reduces injury in the type 2 diabetic heart following ischemia and reperfusion.
American Journal of Physiology 2008; 294:H1282-90 Download PDF

Hart ML, Henn M, Köhler D, Kloor D, Mittelbronn M, Gorzolla IC, Stahl GL, Eltzschig HK.
Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury.
FASEB Journal 2008; 22:278-97 Download PDF

Csencsitsa K, Burrell BE, Lu G, Eichwald EJ, Stahl GL, Bishop DK.
The classical complement pathway in transplantation: Unanticipated protective effects of C1q and role in inductive antibody therapy.
American Journal of Transplantation 2008; 8:1622-30 Download PDF

Busche MN, Walsh MC, McMullen ME, Guikema BJ, Stahl GL.
Mannose-binding lectin plays a critical role in myocardial ischaemia and reperfusion injury in a mouse model of diabetes.
Diabetologia 2008; 51:1544-51 Download PDF

Hart ML, Köhler D, Eckle T, Kloor D, Stahl GL, Eltzschig HK.
Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation.
Arteriosclerosis, Thrombosis, and Vascular Biology 2008; 28:1477-83 Download PDF

Banda NK, Wood AK, Takahashi K, Levitt B, Rudd PM, Royle L, Abrahams JL, Stahl GL, Holers VM, Arend WP.
Initiation of the alternative pathway of complement by immune complexes is dependent on N-glycans in IgG antibodies.
Arthritis and Rheumatism 2008; in press Download PDF

Hart ML, Much C, Köhler D, Schittenhelm J, Gorzolla IC, Stahl GL, Eltzschig HK.
Use of a hanging-weight system for liver ischemic preconditioning in mice.
American Journal of Physiology Gastrointestinal and Liver Physiology 2008; 294:G1431-40 Download PDF View Abstract

Fritzinger DC, Hew BE, Lee JQ, Newhouse J, Alam M, Ciallella JR, Bowers M, Gorsuch WB, Guikema BJ, Stahl GL, Vogel CW.
Derivatives of human complement component C3 for therapeutic complement depletion: a novel class of therapeutic agents.
Advances in Experimental Medicine and Biology 2008; 632:293-307 Download PDF

Hart ML, Much C, Gorzolla IC, Schittenhelm J, Kloor D, Stahl GL, Eltzschig HK.
Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.
Gastroenterology 2008 135:1739-50. Download PDF

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Gorsuch WB, Guikema BJ, Fritzinger DC, Vogel C-W, Stahl GL.
Humanized cobra venom factor decreases myocardial ischemia reperfusion injury.
Molecular Immunology 2009; 47:506-10 Download PDF

La Bonte LR, Dokken B, Davis-Gorman G, Stahl GL, McDonagh PF.
The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart.
Diabetes & Vascular Disease Research 2009; 6:172-80 Download PDF

Harboe M, Garred P, Karlstrøm E, Lindstad JK, Stahl GL, Mollnes TE.
The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification.
Molecular Immunology 2009; 47:373-80. Download PDF

Shannon JG, Cockrell DC, Takahashi K, Stahl GL, Heinzen RA.
Antibody-mediated immunity to the obligate intracellular bacterial Coxiella burnetii is Fc receptor- and complement-independent.
BioMed Central Immunology 2009; 10:26 doi:10.1186/1471-2172-10-26. Download PDF

Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, Szabo C, Stahl GL, Sellke FW.
Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury.
Journal of Thoracic and Cardiovascular Surgery 2009; 138:977-84. Download PDF

Busche MN, Pavlov V, Takahashi K, Stahl GL.
Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin.
American Journal of Physiology: Heart and Circulatory Physiology 2009; 297:H1853-9. Download PDF

Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM.
Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.
Journal of Immunology 2009; 183:5928-37 Download PDF

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Tong HH, Li YX, Stahl GL, Thurman JM.
Enhanced susceptibility of complement-deficient C1qa, factor B and factor B/C2 mice to acute pneumococcal otitis media.
Infection and Immunity 2010; 78:976-83 PMCID: PMC2825922 Download PDF

Takahashi K, Chang W-C, Takahashi M, McClear S, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL*, Van Cott EM* (*co-senior authors).
Mannose-binding lectin deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation.
Immunobiology 2010; 216:96-102 Free Article at PubMed

Banda NK, Levitt B, Wood AK, Takahashi K, Stahl GL, Holers VM, Arend WP.
Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.
Clinical and Experimental Immunology 2010; 159:100-8. PMCID: PMC2802700. Download PDF

Banda NK, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM.
Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis.
Journal of Immunology 2010; 185:5598-606 Download PDF

Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RAB, Schmidt EV.
A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus.
Journal of Biological Chemistry 2010; 285:24729-39 PMCID: PMC2915709 Download PDF

Busche MN, Stahl GL.
Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury.
GMS German Medical Science 2010; 8 Download PDF

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Takahashi K, Chang W-C, Takahashi M, Pavlov V, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL*, Van Cott EM* (*co-senior authors).
Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation.
Immunobiology 2011; 216:96-102 PMCID: PMC2912947 (cover issue) Download PDF

Morrison H, Frye J, Davis-Gorman G, Funk J, McDonagh P, Stahl G, Ritter L.
The contribution of mannose binding lectin to reperfusion injury after ischemic stroke.
Current Neurovascular Research. 2011; 8:52-63 Download PDF

Dahlke K, Wrann CD, Sommerfeld O, Sosssdorf M, Recknagel P, Sachse S, Winter SW, Klos A, Stahl GL, Ma YX, Claus RA, Reinhart K, Bauer M, Riedemann NC.
Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis.
Journal of Immunology 2011; 186:3066-75 Download PDF

Li Q, Li YX, Stahl GL, Thurman JM, He Y, Tong HH.
Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice.
Infection and Immunity 2011; 79:2578-85 Download PDF

Shishova E, Stoll J, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman M, Gutierrez-Juarez R, Cuny GD, Cohen DE.
Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production.
Hepatology 2011; 54:664-74 Download PDF

Banda NK, Takahashi M, Takahashi K, Stahl GL, Hyatt S, Glogowska M, Wiles TA, Endo Y, Fujita T, Holers VM, Arend WP.
Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.
Molecular Immunology 2011; 49:281-9 Download PDF

Sebastian B, Roychowdhury S, Tang H, Hillian A, Feldstein A, Stahl G, Takahashi K, Nagy L.
Identification of a CYP2E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice.
Journal of Biological Chemistry 2011; 286:35989-97 Download PDF

Takahashi K, Saha D, Shattino I, Pavlov V, Stahl GL, Finnegan P, Melo MF.
Complement C3 is involved with ventilator-induced acute lung injury.
International Immunopharmacology 2011; 11:2138-43 Download PDF

Takahashi K, Chang W-C, Moyo P, White MR, Meelu P, Verma A, Stahl GL, Hartshorn KL, Yajnik V.
Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin.
Open Journal of Immunology 2011; 1:41-9 Download PDF

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van de Pol P, Schlagwein N, van Gijlswijk DJ, Berger SP, Roos A, Bajema IM, de Boer HC, de Fijter JW, Stahl GL, Daha MR, van Kooten C.
Mannan-Binding Lectin Mediates Renal Ischemia/Reperfusion Injury Independent of Complement Activation.
American Journal of Transplantation 2012; 12:877-87 Download PDF

Pavlov VI, La Bonte LR, Baldwin WM, Markiewski M, Lambris J, Stahl GL.
Absence of mannose-binding lectin prevents hyperglycemic cardiovascular complications.
American Journal of Pathology 2012; 180:104-112 Download PDF

La Bonte LR, Pavlov VI, Tan YS, Takahashi K, Takahashi M, Banda NK, Fujita T, Stahl GL.
MBL-associated serine protease -1 (MASP-1) is a significant contributor to coagulation in a murine model of occlusive thrombosis.
Journal of Immunology 2012; 188:885-91 Download PDF

Burk A-M, Martin M, Flier, MA, Rittirsch D, Helm M, Lampl L, Bruckner U, Stahl GL, Blom AM, Perl M, Gebhard F, Huber-Lang M.
Early complementopathy after multiple injuries in humans.
Shock 2012; 37:348-54 Download PDF

Larvie M, Shoup T, Chang W, Chigweshe L, Hartshorn K, White MR, Stahl GL, Elmaleh DR, Takahashi K.
Mannose-binding lectin binds to amyloid protein and modulates inflammation.
Journal of Biomedicine and Biotechnology 2012; vol. 2012; Article ID 929803, 12 pages, 2012. doi:10.1155/2012/929803 Download PDF Full Article

Banda NK, Hyatt S, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM.
Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice.
Journal of Immunology 2012; 188:1469-78 Download PDF

Zou, C, La Bonte LR, Pavlov VI, Stahl GL.
Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin.
Frontiers in Immunology 2012; 3:15. doi: 10.3389/fimmu.2012.00015 Download PDF

Ali YM, Lynch NJ, Haleem KS, Kadioglu A, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Wallis R, Stover CM, Andrew PW, Schwaeble WJ.
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.
PLoS Pathogens 2012; 8:e1002973 Download PDF

Harboe M, Garred P, Lindstad JK, Pharo A, Muller F, Stahl GL, Lambris JD, Mollnes TE.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
Journal of Immunology 2012; 189:2606-13 Download PDF

Stahl GL, Shernan SK, Smith PK, Levy JH.
Complement activation and cardiac surgery: A novel target for improving outcomes.
Anesthesia and Analgesia (Invited Review) 2012; 115:759-71 Download PDF

Gorsuch WB, Chrysanthou E, Schwaeble WJ, Stahl GL.
The complement system in ischemia-reperfusion injuries.
Immunobiology (Invited Review) 2012; 217:1026-33 Download PDF

Pavlov VI, Skjoedt M-O, Tan YS, Rosbjerg A, Garred P, Stahl GL.
Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis.
Circulation 2012, 126:2227-35 Download PDF

Orsini F, Villa P, Parrella S, Zangari R, Zanier ER, Gesuete R, Stravalaci M, Fumagalli S, Ottria R, Reina JJ, Paladini A, Micotti E, Ribeiro-Viana R, Rojo J, Pavlov VI, Stahl GL, Bernardi A, Gobbi M, De Simoni M-G.
Targeting mannose binding lectin confers long lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.
Circulation 2012; 126:1484-94 Download PDF

Li Q, Li YX, Douthitt K, Stahl GL, Thurman JM, Tong HH.
Role of the alternative and classical complement activation pathway in complement mediated killing against Streptococcus pneumoniae colony opacity variants during acute pneumococcal otitis media in mice.
Microbes and Infection 2012; 14:1308-12 Download PDF

Elvington A, Atkinson C, Zhu H, Jin Y, Takahashi K, Stahl GL, Kindy MS, Tomlinson S.
The alternative complement pathway propagates inflammation and injury in murine ischemic stroke.
Journal of Immunology 2012; 189:4640-7 Download PDF

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Brudner M, Karpel M, Lear C, Chen L, Yantosca LM, Scully C, Sarraju A, Sokolovska A, Zariffard MR, Eisen DP, Mungall BA, Kotton DN, Omari A, Huang C, Farzan M, Takahashi K, Stuart L, Stahl GL, Ezekowitz AB, Spear GT, Olinger GG, Schmidt EV, Michelow IC.
Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors.
PLOS ONE 2013; 8:e60838 Download PDF

Arend WP, Mehta G, Antonioli A, Takahashi M, Takahashi K, Stahl GL, Holers VM, Banda NK.
Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice.
Journal of Immunology 2013; 190:6423-33 Download PDF

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Sweigard JH, Yanai R, Thanos A, Gaissert P, Stahl GL, Lambris JD, Conner KM.
The alternative complement pathway regulates pathological angiogenesis in the retina.
FASEB Journal 2014; 28(7):3171-82 PMC4062823 Download PDF

Tong HH, Lambert G. Li YX, Thurman JM, Stahl GL, Douthitt K, Clancy C, He Y, Bowman AS.
Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice.
PLoS One 2014; Apr 16;9(4):e95160 Download PDF

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Pavlov VI, Tan YS, McClure EE, La Bonte LR, Zou C, Gorsuch WB, Stahl GL.
Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model.
American Journal of Pathology 2015; 185(2):347-55

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